While the company doesn’t have any other products on the market yet, its flu vaccine NanoFlu could be ready for potential FDA approval. The companies are on track to file an emergency use application with the U.S. FDA later this month if pending data indicates that the vaccine is safe. This is an important addition to the manufacturing capacity needed by global pharmaceutical and vaccine companies in the ongoing fight against COVID-19. While most vaccine stocks declined last week, amid a broader sell-off in the markets, they are likely to come back into the spotlight as efficacy data from late-stage trials is expected from frontrunners Pfizer (NYSE: PFE) and Moderna (NASDAQ: MRNA) in the coming weeks. Our indicative theme of Covid-19 Vaccine stocks – which includes a diverse set of U.S.-based pharma and biotech companies developing Covid vaccines – is up by about 560% year-to-date, on an equally weighted basis, compared to the S&P 500 which has gained just about 4% over the same period. While the company had to pause trials in mid-October after an illness was reported in a volunteer, the company is now preparing to resume trials. The companies are on track to file an emergency use application with the U.S. FDA later this month if pending data indicates that the vaccine is safe. [Updated 11/11/2020] Why Pfizer’s Vaccine Data Is Good News For Moderna. [7] Moderna’s vaccine offers an efficacy that’s similar to Pfizer’s and can apparently be stored at refrigerator-like temperatures for 30 days. Not so fast: analysts, After Admitting Mistake, AstraZeneca Faces Difficult Questions About Its Vaccine. AstraZeneca’s vaccine, on the other hand, faces concerns regarding some gaps in its trial data, which could undermine its reported results. All Rights Reserved, This is a BETA experience. Once the vaccine is produced, the fill-finish operation – which is the process of filling vials and packaging the vaccine for distribution – is handled by Catalent Pharmaniaga is ready to efficiently distribute Covid-19 vaccines as soon as it receives the go-ahead from the government. Some countries like the United States and United Kingdom have already begun vaccinating priority groups and the public. The Vaccine Business Unit based in Singapore hosts a laboratory for analytics and development of vaccines to protect against important infectious diseases in the region. Led by MIT engineers and Wall Street analysts, Trefis (through its dashboards platform dashboards.trefis.com) helps you understand how a company's products, that you touch, read, or hear about everyday, impact its stock price. Two shots of the vaccine will be required per person. Aside from the approved Sinopharm vaccine, China has four vaccine candidates which have reached Phase 3 trials. Arcturus in a statement on Tuesday said that this first phase of the trial … [Updated 12/1/2020]Moderna (NASDAQ In a recent poll by NHK, 36% of respondents didn't want to take a Covid-19 vaccine. Switzerland-based Lonza, one of the world’s largest pharmaceutical services companies, will produce the key mRNA active ingredient for the vaccine in New Hampshire and Switzerland. Singapore is building up its vaccine manufacturing capacity in order to offer fill and finish contract manufacturing services to vaccine developers, Singapore Prime … Being a clinical-stage biotech, Moderna also lacks the sophisticated supply chain of big pharma companies such as Pfizer and Johnson & Johnson. NSA Will Install Trump Loyalist Michael Ellis As Its General Counsel, Stocks This Week: Sell Short General Dynamics And Transocean, Fauci Warns Of ‘Ominous’ New Covid-19 Strains, Says Biden Can Achieve Aggressive Goal Of Vaccinating 100 Million In 100 Days, January’s Message: 2021 Is Not 2020. The country will also receive 2 million doses of the Sinovac vaccine in three batches, delivered in February, March and April. As well as global, regional and local commercial operations, we have a significant manufacturing presence in Singapore, comprising two global manufacturing supply sites and a vaccines manufacturing facility. Other areas? How Will The Covid-19 Vaccine Impact Moderna’s EPS? According to the Hong Kong government, the Sinovac vaccine will be made in Beijing, but the Pfizer-BioNTech vaccine will come from Europe. The stock is down by -5.1% this year. in the U.S., and by ROVI and Recipharm outside the U.S. See our indicative theme of  Covid-19 Vaccine stocks which includes U.S.-listed pharma and biotech companies. (related: How Will The Covid-19 Vaccine Impact Moderna’s EPS?) Chan, however, did not … Like Japan, South Korea has yet to approve any vaccine, but has signed contracts with a number of pharmaceutical companies for access to their vaccine candidates. Once a large percentage of the global population is vaccinated (likely by 2022 or 2023) the earnings potential of the Covid vaccine will diminish. Data sources: Biotechnology Innovation Organizati… What if you’re looking for a more balanced portfolio instead? Sanofi. Johnson & Johnson (JNJ): Unlike most other vaccine candidates, which are likely to require two shots, J&J is targeting a single-dose vaccine. The vaccine will also be the first to seek emergency use approval from the FDA. Moreover, the mRNA technology that Moderna (and Pfizer) are using requires specialized manufacturing equipment. Over 500 employees based in Singapore are dedicated to empowering the lives of patients all over the world. The vaccines will be free for the public, Widodo said in December. There are still some concerns though. The Southeast Asian carrier is in talks with some of the vaccine manufacturers, and working out details of the planned trials, according to The … (Photo illustration by Artur Widak/NurPhoto via Getty Images), EY & Citi On The Importance Of Resilience And Innovation, Impact 50: Investors Seeking Profit — And Pushing For Change. Here’s a high-quality portfolio to beat the market, with about 120% return since 2016, versus about 60% for the S&P 500. Singapore is home to Sanofi’s regional headquarters, local head office, manufacturing facility as well as regional export center. SINGAPORE - When asked if they would take the Covid-19 jab once it hits the market, some well-known Singaporeans had mixed views. We estimate that the vaccine will add roughly $6 to Moderna’s EPS each year over 2021 and 2022. The company is likely to have efficacy data from late-stage trials available shortly. Several companies already had vaccine platforms targeting other coronaviruses such as MERS and SARS. The theme is up by about 540% year-to-date versus about 10% for the S&P 500. The stock has more than doubled over the last month as the company began publishing efficacy data. There are a couple of reasons why Moderna’s vaccine is much sought after. SINGAPORE, Dec 21 — Singapore received its first shipment of Covid-19 vaccine this evening on board a Singapore Airlines (SIA) cargo flight from Belgium, where it was manufactured. See our indicative theme of  Covid-19 Vaccine stocks – which includes U.S.-listed pharma and biotech companies. While Pfizer‘s (NYSE: PFE) surprisingly strong initial Covid-19 vaccine efficacy readout likely marks the beginning of the end of the Covid-19 pandemic, it probably doesn’t mean too much for Pfizer stock, given the limited potential profits and challenges with distribution. : MRNA) published final results from its 30,000-person phase 3 trial of its Covid-19 vaccine and indicated that it would apply for emergency use authorization with the U.S. FDA. SINGAPORE has made arrangements with various pharmaceutical companies to facilitate their clinical trials and drug development in Singapore, with the government having attracted a few players to establish vaccine manufacturing capabilities here. However, there are a couple of factors that could help the company scale up quickly. A coolroom at Singapore's Changi Airport, preparing for the arrival of its first shipment of Pfizer-BioNTech vaccines, on December 16, 2020. Most countries in Southeast Asia have not approved vaccines yet -- but nearly all have signed deals to receive China's vaccine candidates, as well as signing additional deals with other providers. While there are two other vaccines by drug majors Pfizer and AstraZeneca that have reported phase 3 results, it looks like Moderna’s vaccine offers the best balance of efficacy and ease of storage and distribution. The vaccine was over 94% effective in preventing Covid-19 and 100% effective in preventing severe cases of infection – meaning that no one who received the vaccine developed a serve case of the infection. Currently, there is only one type of Covid-19 vaccine available in Singapore. Firstly, supply will remain an issue in the near-term. Among those who have already received the vaccine, fewer than 0.1% developed a light fever, and about two people per million developed "relative serious adverse reactions" such as allergies, according to Zeng. Arcturus Therapeutics announced on Dec. 28 that it received approval from the Singapore Health Sciences Authority to proceed with a Phase 2 clinical study of its vaccine candidate ARCT-021, also known as LUNAR-COV19. [Updated 11/17/2020] What The Covid Vaccine Means For Moderna Stock, On Monday, Moderna (NASDAQ: MRNA) stock rallied by over 10% after the company said that its Covid-19 vaccine – which is based on messenger RNA technology – was 94.5% effective based on preliminary data. Singapore is in talks with major suppliers of COVID-19 vaccines on the possibility of being a regional distributor and playing a part in the final stages of vaccine production, Trade and Industry Minister Chan Chun Sing said on Monday. Japanese Prime Minister Yoshihide Suga at a press conference in Tokyo on January 4. See all Trefis Price Estimates and Download Trefis Data here, What’s behind Trefis? Most other countries are still waiting on local regulators to approve vaccine candidates before they can roll out inoculation programs -- and in the meantime, are scrambling to sign deals with pharmaceutical companies to buy the coveted doses in advance. We maintain strict product-quality standards and multiple supply-chain safeguards to ensure the efficacy, safety and supply of our products - no matter where our medicines and vaccines are manufactured. The country is still evaluating other candidates, including China's. The Pfizer-BioNTech vaccine arrived at Changi Airport aboard a scheduled SIA Boeing 747-400 freighter service from the Belgian capital Brussels at about 7.35pm. So how is the company going to meet demand? Updated 0231 GMT (1031 HKT) January 9, 2021. Germany’s CordenPharma will produce the lipids – which are used to deliver the mRNA. No estimate was given for Novavax. On Thursday, December 24, 2020, in Dublin, Ireland. [1] The companies … This is positive news, considering that Moderna has no real manufacturing track record and has never produced or sold a commercial drug prior to the Covid-19 shot. Novavax (NVAX), a vaccine development company, began late-stage trials of its Covid vaccine in the U.K in September, and large-scale phase 3 trials are due to begin in the U.S. and Mexico this month. See How It’s Powering New Collaboration and What-Ifs For CFOs and Finance Teams | Product, R&D, and Marketing Teams, Led by MIT engineers and Wall Street analysts, Trefis (through its dashboards platform dashboards.trefis.com) helps you understand how a company's products, that you. Brief post-vaccination advice will also be printed on the card. Competition is also likely to mount as there are likely to be several more successful vaccine candidates from other companies in the coming quarters. Moderna’s vaccine uses messenger RNA (mRNA) technology – which has never been used in a vaccine before but could be easier to scale up. The two vaccines: The Serum Institute of India (SII) has been manufacturing the vaccine developed by Oxford University and AstraZeneca. The strong efficacy and the speed at which the vaccine was developed should essentially reduce the perceived risk surrounding the rest of Moderna’s pipeline of 21 vaccines and therapies for rare diseases. The central government will cover the cost, allowing residents to receive the vaccine. 6. Pfizer’s vaccine is about 95% effective based on phase 3 data, but it needs to be stored at extremely cold temperatures of minus 94 degrees Fahrenheit, calling for specialized freezers. See our indicative theme of  Covid-19 Vaccine stocks – which includes U.S.-listed pharma and biotech companies. KUALA LUMPUR, Dec 28 — Pharmaniaga Bhd is ready to efficiently distribute Covid-19 vaccines which are expected to be ready by the first quarter of 2021, as soon as it receives the go-ahead from the government. The company already has supply agreements with the U.S., Canada, Japan, the U.K., Israel, Qatar, and Switzerland and is also having discussions with several other countries. The company has 21 programs underway, around 13 of which are in the clinical stage. Moderna (MRNA) , a clinical-stage biotech company, is carrying out phase 3 trials of its Covid-19 vaccine, completing enrollment of 30,000 participants. By the end of March, four million people should have been vaccinated, according to Prime Minister Scott Morrison. The stock has soared 2,000% year-to-date. On the other hand, vaccines being developed by the likes of Oxford- AstraZeneca, Novavax, and others can be held at regular refrigerated temperatures. Read more at The Business Times. For perspective, the Covid-19 vaccine was apparently designed within a few days. That said, Moderna’s success with Covid doesn’t guarantee that its vaccines and therapeutics in other areas, such as cancer, will be as effective. [Updated 11/4/2020] Covid-19 Vaccine stocks. The platform uses extensive data to show in a single snapshot what drives the value of a company's business. Janssen vaccinations could start in the second quarter, and Pfizer vaccines will arrive in the third quarter, according to Prime Minister Chung Sye-kyun. While Moderna intends to produce between 500 million to 1 billion doses of its vaccine over 2021, it has no real manufacturing track record and has never produced or sold a commercial drug to date. The vial filling and packaging will be handled by Catalent, a contract manufacturing company. No Choosing Of Vaccines. high-quality portfolio to beat the market, Lonza gets Swiss OK to start Moderna vaccine production -paper, How mRNA vaccines from Pfizer and Moderna work, Moderna’s Covid-19 vaccine was designed in just two days, Pfizer-BioNTech COVID-19 vaccine data ‘open the floodgates’ for mRNA in infectious disease. (Related: Are Covid Vaccine Stocks Worth Investing In?) The company is likely to have data on whether its vaccine works or not by this month, and has noted that it would seek emergency approval from the FDA if the vaccine is at least 70% effective. On top of this, vaccine manufacturers are required to … Arcturus (Nasdaq: ARCT) hopes the compound will prove effective as a vaccine against SARS-CoV-2, the virus that causes COVID-19. As we’ve said before, Moderna’s Covid-19 vaccine is likely to emerge as the most sought-after vaccine in developed markets, considering its stellar efficacy rates and relative ease of storage. Surprisingly, the founders of Trefis discovered that along with most other people they just did not understand even the seemingly familiar companies around them: Apple, Google, Coca Cola, Walmart, GE, Ford, Gap, and others. In fact, we think that the strong data from the vaccine – which is developed using messenger RNA (mRNA) technology could actually mean a lot more for Moderna (NASDAQ: MRNA), another Covid-19 vaccine player, whose entire drug pipeline is based on mRNA technology. Takeda Vaccines Pte. © 2021 Forbes Media LLC. Both governments have said the vaccines will be free and voluntary for citizens. You can play with assumptions, or try scenarios, as-well-as ask questions to other users and experts. See our indicative theme of  Covid-19 Vaccine stocks – which includes U.S.-listed pharma and biotech companies. “We made arrangements with pharmaceutical companies to facilitate their clinical trials and drug development in Singapore and attracted a few to establish vaccine manufacturing capabilities here.” Singapore is the regional headquarters of our Emerging Markets and Asia Pacific pharmaceutical and consumer healthcare businesses. CTLT The results are surprisingly strong, considering that the U.S. FDA had set a baseline efficacy of just 50% for the approval for Covid-19 vaccines. If Moderna’s success is for some reason limited to certain infectious disease vaccines, its long term outlook might not be as promising, given the lower margins that vaccines typically command. The stock is down by about -7.6% this year. The Oxford-AstraZeneca vaccine could be approved in February. Can Senate Handle Trump’s Impeachment And A New Stimulus Package At Once? The theme is up about 3x over the last 2 years. Pfizer’s vaccine could also face logistical issues, considering that the vaccine needs to be stored at a temperature of minus 94 degrees Fahrenheit. [12/10/2020] Can Moderna Rise To The Manufacturing Challenge? This could potentially limit the use of Pfizer’s vaccine to clinics and hospitals that have the appropriate storage facilities. For example, not all viruses are similar to Covid, which mRNA might be better at mimicking. Called Lunar-Cov19, the vaccine is developed by Duke-NUS Medical School and American pharmaceutical company Arcturus Therapeutics. The theme is up by about 721 % year-to-date versus about 13% for the S&P 500. Moderna’s Cytomegalovirus (CMV) vaccine, which is currently in phase 2 studies and could move to phase 3 in 2021, is likely to be the company’s first candidate for approval after its Covid-19 vaccine. Also, vaccines traditionally have lower profitability versus prescription drugs. This enabled them to rapidly prototype experimental vaccines for immunizing against the novel coronavirus that causes COVID-19. Opinions expressed by Forbes Contributors are their own. The stock is up 253% this year. MSD manufactures medicines and vaccines that are sold in more than 140 countries. Here's what we know about Covid-19 vaccines in Asia Pacific. Combined with the large public interest in facilitating vaccine access, these margins may face even more downward pressure. — Bernama pic. SII is allowed to produce the Oxford-AstraZeneca vaccine for use within India, but the government has barred them for export until at least March or April -- meaning other countries may have to source their Oxford-AstraZeneca doses from other production sites. We think it largely is, but there are some risks as well. Following are all of the companies that are actively developing COVID-19 vaccines either on their own or in partnership with another drugmaker. An illustrative photo showing medical syringes seen in front of Moderna logo displayed on screens in ... [+] the background on Christmas Eve. Pfizer (PFE) is working with German partner BioNTech on a Covid-19 vaccine. novartis singapore pharmaceutical manufacturing Novartis was created in 1996 through the merger of Ciba-Geigy and Sandoz and has a rich history spanning over 200 years. While the EPS impact of the Covid-19 vaccine could be fleeting, the validation of Moderna’s messenger RNA (mRNA) technology could be far more consequential for investors. ), More importantly for Moderna investors, the vaccine’s results also bode well for the rest of the company’s pipeline, which is entirely based on mRNA technology which has never been used previously in commercial drugs. While messenger RNA (mRNA) based vaccines were touted to be more potent and quicker to deploy compared to traditional vaccines, they have never been used commercially to date. This is also the age range recommended by most of the manufacturers and for which the vaccines are approved for use in Singapore by the Health Sciences Authority. [2], Moderna is working with multiple partners to produce its vaccine. In Asia, only a handful of countries have reached this stage -- the biggest being China and India, which have the extensive manufacturing capabilities necessary to serve as regional vaccine production hubs. mRNA offers significant flexibility with vaccine and potentially drug development. China's capabilities mean it could produce vaccines developed by other countries as well. (related: How Will The Covid-19 Vaccine Impact Moderna’s EPS?) Sanofi is another of the top vaccine manufacturers in the world specialized in research and … [3]. While Pfizer stock was up by almost 8% following the news, we think it’s unlikely that the vaccine will meaningfully move the needle for the company for multiple reasons. (related: A Look At Moderna’s Pipeline Beyond The Covid Vaccine). NDAQ It did not disclose where the AstraZeneca vaccine would be produced. Australia expects to start administering the first dose in mid-to-late February to priority groups, including quarantine and border workers, frontline healthcare workers, and residents in aged and disability care. The country is also working to secure deals with American companies. Once the genetic code of a virus is available, Moderna essentially adapts messenger RNA to trigger the immune system to produce protective antibodies without using the actual part of the virus, unlike traditional vaccines. On Thursday, December 24, 2020, in Dublin, Ireland. The Pfizer-BioNTech vaccine is expected to approved by Australian regulators by the end of January, Morrison said. [11/27/2020] What’s Happening With Moderna Stock?Moderna (NASDAQ: MRNA) stock rallied by over 10% on Wednesday’s trading after the European Union agreed to buy 80 million doses of its Covid-19 vaccine, with an option to buy up an additional 80 million doses. While Moderna’s stock trades at about $150 per share, its valuation still looks reasonable at about 25x our projected 2020 EPS. Chinese leaders have promised a growing list of developing countries priority access to its successful vaccines. (CNN)One year after the Covid-19 outbreak began, countries around the world are racing to secure and distribute vaccines to their citizens. Moderna’s vaccine will also be more expensive than rivals, as it is likely to cost between $25 and $37 per dose, depending on the volume of the order, compared to about $19 per dose for the Pzifer vaccine. [6] There could be challenges in areas such as Immuno-Oncology as well, where Moderna is betting big. | Takeda. (Photo illustration by Artur Widak/NurPhoto via Getty Images). the background on Christmas Eve. Overall, Moderna’s vaccine could offer the best of both worlds – high effectiveness and easier logistics, although it could be slightly more difficult to manufacture compared to Pfizer’s. Trefis is currently used by hundreds of thousands of investors, company employees, and business professionals. You may opt-out by. The country will also secure enough vaccines to cover Pacific Islands including Samoa, Tuvalu, Tokelau, Niue, and the Cook Islands, according to CNN affiliate, Australia's Pfizer doses will be manufactured in the US and Europe, the Oxford-AstraZeneca vaccine will be. Has more than 140 countries immunizing against the novel coronavirus that causes.... Doses of the vaccine will be handled by Catalent, a contract manufacturing company government is to. Multiple partners to produce its vaccine, allowing residents to receive the will! 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